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The influence of four different anticoagulants on dynamic light scattering of platelets
Author(s) -
Raczat T.,
Kraemer L.,
Gall C.,
Weiss D. R.,
Eckstein R.,
Ringwald J.
Publication year - 2014
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/vox.12150
Subject(s) - platelet , theophylline , chemistry , medicine , ethylene diamine , dipyridamole , endocrinology , nuclear chemistry
For testing of dynamic light scattering of platelets with Thrombo LUX ( TLX ) in platelet‐rich plasma ( PRP ) derived from venous whole blood (v WB ), anticoagulation is needed. We compared TLX score in PRP s containing citrate, ethylene‐diamine‐tetraacetic‐acid ( EDTA ), citrate‐phosphate‐dextrose‐adenine ( CPDA ) or citrate‐theophylline‐adenosine‐dipyridamole. Initial and late TLX scores were measured after 30–120 min or four to six hours, respectively. Compared with citrate, mean differences in initial TLX score were only significant for CPDA . Also, mean differences between initial and late TLX scores were only significant for CPDA . TLX failed to detect EDTA ‐induced platelet alterations. The clinical relevance of TLX needs further studies.