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JK null alleles identified from Japanese individuals with Jk(a−b−) phenotype
Author(s) -
Onodera T.,
Sasaki K.,
Tsuneyama H.,
Isa K.,
Ogasawara K.,
Satake M.,
Tadokoro K.,
Uchikawa M.
Publication year - 2014
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/vox.12117
Subject(s) - allele , phenotype , null allele , genetics , biology , exon , gene , microbiology and biotechnology
The Kidd blood group system consists of three common phenotypes: Jk(a+b−), Jk(a−b+) and Jk(a+b+), and one rare phenotype, Jk(a−b−). Jk a /Jk b polymorphism is associated with c.838G>A (p.Asp280Asn) in exon 9 of the JK ( SLC 14A1 ) gene, and the corresponding alleles are named JK *01 and JK *02 . The rare phenotype Jk(a−b−) was first found in a Filipina of Spanish and Chinese ancestry, and to date, several JK null alleles responsible for the Jk(a−b−) phenotype have been reported. We report seven novel JK null alleles, 4 with a JK *01 background and 3 with a JK *02 background, identified from Jk(a−b−) Japanese.