JK   null alleles identified from Japanese individuals with Jk(a−b−) phenotype | Zendy

Onodera T. | Zendy; Sasaki K. | Zendy; Tsuneyama H. | Zendy; Isa K. | Zendy; Ogasawara K. | Zendy; Satake M. | Zendy; Tadokoro K. | Zendy; Uchikawa M. | Zendy

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JK null alleles identified from Japanese individuals with Jk(a−b−) phenotype

Author(s) -

Onodera T.,

Sasaki K.,

Tsuneyama H.,

Isa K.,

Ogasawara K.,

Satake M.,

Tadokoro K.,

Uchikawa M.

Publication year - 2014

Publication title -

vox sanguinis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.68

H-Index - 83

eISSN - 1423-0410

pISSN - 0042-9007

DOI - 10.1111/vox.12117

Subject(s) - allele , phenotype , null allele , genetics , biology , exon , gene , microbiology and biotechnology

The Kidd blood group system consists of three common phenotypes: Jk(a+b−), Jk(a−b+) and Jk(a+b+), and one rare phenotype, Jk(a−b−). Jk a /Jk b polymorphism is associated with c.838G>A (p.Asp280Asn) in exon 9 of the JK ( SLC 14A1 ) gene, and the corresponding alleles are named JK *01 and JK *02 . The rare phenotype Jk(a−b−) was first found in a Filipina of Spanish and Chinese ancestry, and to date, several JK null alleles responsible for the Jk(a−b−) phenotype have been reported. We report seven novel JK null alleles, 4 with a JK *01 background and 3 with a JK *02 background, identified from Jk(a−b−) Japanese.

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