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Prevalence of T reponema pallidum DNA among blood donors with two different serologic tests profiles for syphilis in S ão P aulo, B razil
Author(s) -
Ferreira S. C.,
AlmeidaNeto C.,
Nishiya A. S.,
DiLorenzoOliveira C.,
Ferreira J. E.,
Alencar C. S.,
Levi J. E.,
Salles N. A.,
MendroneJunior A.,
Sabino E. C.
Publication year - 2014
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/vox.12111
Subject(s) - syphilis , treponema , serology , virology , medicine , immunology , infectivity , treponematosis , syphilis serodiagnosis , transmission (telecommunications) , antibody , sexually transmitted disease , virus , human immunodeficiency virus (hiv) , electrical engineering , engineering
The presence of Treponema pallidum DNA was assessed by real‐time PCR in samples of blood donors with reactive serologic tests for syphilis. Treponema pallidum DNA was detected in two (1·02%) of 197 samples of VDRL >8, EIA + and FTA ‐ ABS + donors, and in no sample from 80 VDRL −, EIA + and FTA ‐ ABS + donors. Donors VDRL −, EIA + and FTA ‐ ABS + lack demonstrable T. pallidum DNA in their blood and are unlike to transmit syphilis. Donors VDRL >8, EIA + and FTA ‐ ABS + carry the risk of syphilis infectivity even in concomitance to antibodies detection. Serologic screening for syphilis may still play a role to prevent its transfusion transmission.