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Approach of using established and new laboratory tests to more comprehensively investigate noninfectious and nonhemolytic transfusion reactions – along with the experience in J apan
Author(s) -
Hirayama F.
Publication year - 2013
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/vox.12057
Subject(s) - medicine , transfusion reaction , immunology , antibody , intensive care medicine , basophil activation , pathogenesis , basophil , immunoglobulin e
Background and Objectives Noninfectious and nonhaemolytic transfusion reactions are the most common type of transfusion reactions. Several new tests have been made, helping diagnosis and understanding of their pathogenesis. This manuscript provides a review of the literature on currently available tests in association with the approach in J apan. Materials & Methods Primarily by using key words, more than 100 pertinent articles in the M edline database were identified and reviewed. Results Numbers of laboratory tests are available including those for plasma protein levels, plasma protein antibodies, leucocyte and platelet antibodies, serum N ‐terminal‐pro‐brain natriuretic peptide levels, serum tryptase levels and genetic microchimerism. Cross‐match tests, such as basophil activation test and neutrophil activation test, are also available to determine a causal relationship between the reaction and transfusion. Conclusions Several tests should help to confirm diagnosis and determine causal relationship between adverse reactions and transfusion and to gain an insight into the mechanism of the reaction in some cases, although some of the recently developed tests have not been completely validated.