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Prospective multicentre study of the effect of voluntary plasmapheresis on plasma cholesterol levels in donors
Author(s) -
RosaBray M.,
Wisdom C.,
Wada S.,
Johnson B. R.,
GrifolsRoura V.,
GrifolsLucas V.
Publication year - 2013
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/vox.12031
Subject(s) - plasmapheresis , medicine , cholesterol , prospective cohort study , ldl cholesterol , population , donation , apheresis , cohort , cohort study , endocrinology , immunology , platelet , antibody , economic growth , environmental health , economics
Background and Objectives LDL apheresis is used to treat patients with familial hypercholesterolaemia, and low‐volume plasmapheresis for plasma donation may similarly lower cholesterol levels in some donors. This study was designed to assess the effect of plasmapheresis on total, LDL and HDL cholesterol levels in a plasma donor population. Materials and Methods This was a prospective, unblinded longitudinal cohort study in which a blood sample was obtained for analysis before each donation. Data from 663 donors were analysed using a multivariable repeated measures regression model with a general estimating equations approach with changes in cholesterol as the primary outcome measure. Results The model predicted a significant decrease in total and LDL cholesterol for both genders and all baseline cholesterol levels ( P < 0·01). The greatest total cholesterol decreases (women, −46·8 mg/ dL ; men, −32·2 mg/ dL ) were associated with high baseline levels and 2–4 days between donations. Small but statistically significant increases ( P ≤ 0·01) in HDL cholesterol were predicted for donors with low baseline levels. Conclusions These results suggest that, in donors with elevated baseline cholesterol levels, total and LDL cholesterol levels may decrease during routine voluntary plasmapheresis.