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Measuring clinical bleeding using a standardized daily report form and a computer algorithm for adjudication of WHO bleeding grades
Author(s) -
Middelburg R. A.,
Ypma P. F.,
Meer P. F.,
WordragenVlaswinkel R. J.,
Eissen O.,
Kerkhoffs J. L.
Publication year - 2013
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/vox.12030
Subject(s) - adjudication , bleed , algorithm , medicine , surgery , computer science , law , political science
Bleeding is increasingly considered an important end point in clinical platelet transfusion studies. Accurate recording and adjudication into well‐defined bleeding grades, however, remains a major challenge. Methods We developed a computer algorithm for automatic adjudication. The algorithm's results were compared to those of three independent adjudicators. Results For one of 1186 bleeding days, the clinical report form ( CRF ) was filled out incorrectly, and the algorithm therefore missed one grade‐1 skin bleed. For two bleeding days, the adjudicators incorrectly classified a grade‐2 skin bleed as grade‐1 while the algorithm correctly classified these days. The algorithm saved approximately six person‐hours of adjudication time for the adjudication of 1186 days from 60 patients. Discussion The algorithm can be an invaluable tool for adjudicating large amounts of bleeding data.