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Effects of platelet concentrate storage time reduction in patients after blood stem cell transplantation
Author(s) -
Heuft H.G.,
Goudeva L.,
Krauter J.,
Peest D.,
Buchholz S.,
Tiede A.
Publication year - 2013
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/vox.12015
Subject(s) - medicine , platelet , platelet transfusion , transplantation , surgery , blood transfusion , anesthesia
Objective To evaluate the clinical effect of platelet concentrate ( PC ) transfusions after PC storage time reduction to 4 days. Patients and Methods This was a single‐centre cohort study comparing two 3‐month periods of time, before and after the reduction of PC storage time from 5 to 4 days. Seventy‐seven consecutive patients with PC transfusions were enrolled after blood stem cell transplantation. Corrected platelet count increment ( CCI ) on the morning after transfusion, time to next platelet transfusion, need for red blood cell ( RBC ) transfusion and clinical bleeding symptoms were compared. Results Platelet concentrate storage time was reduced between period 1 (storage for up to 5 days, median storage time 78 h, range 11–136 h) and period 2 (storage for up to 4 days, median storage time 53 h, range 11–112 h). Patients were comparable for age, weight, body surface area, underlying disorder, type of transplantation and transfused platelet dose. The CCI increased from a median of 4 (range 0–20) to 8 (0–68) × 10 9 /l per 10 11 platelets/m 2 ( P < 0·0001). Time to next PC transfusion increased from 1·1 to 2·0 days ( P < 0·0001). Any bleeding symptom was noted in 20 of 36 patients (56%) vs. 9/41 patients (22%, P < 0·01). Nose bleeds, haematuria and bleeding at more than one site were significantly reduced. Frequency of RBC transfusion within 5 days after PC transfusion was reduced from 74 to 58% ( P < 0·0001). Conclusion Platelet concentrate storage time shortening was associated with highly significant CCI increase, reduced RC needs and lower patient numbers with bleeding events.