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Choroidal neuroendocrine neoplasia in a dog
Author(s) -
Lucyshyn Danica R.,
Knickelbein Kelly E.,
Hollingsworth Steven R.,
Reilly Christopher M.,
Brust Kelsey D.,
Visser Lance C.,
Burge Rhonda,
Willcox Jennifer L.,
Maggs David J.
Publication year - 2021
Publication title -
veterinary ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.594
H-Index - 50
eISSN - 1463-5224
pISSN - 1463-5216
DOI - 10.1111/vop.12875
Subject(s) - medicine , chemodectoma , choroid , histopathology , enucleation , pathology , intracardiac injection , ciliary body , abdominal ultrasonography , radiology , paraganglioma , retina , surgery , computed tomography , physics , optics
Objective To report onset and progression of clinical signs of a neuroendocrine neoplasm (NEN) presumed metastatic to the choroid in a dog. Animals Studied A 7.5‐year‐old female spayed German shepherd dog mix referred for advanced imaging and evaluation of a subretinal mass in the right eye. Procedures Procedures performed included general physical and ophthalmic examinations; ocular, orbital, and abdominal ultrasonography; thoracic radiographs; cranial magnetic resonance imaging; serologic testing for infectious agents; analysis of hematologic as well as serum and urine biochemical parameters; echocardiography; electrocardiography; cytologic assessment of lymph nodes; and histopathology and immunohistochemistry of the enucleated globe. Results Examination and imaging identified a pigmented mass within and expanding the superior choroid. Following enucleation, a choroidal NEN with tumor emboli in scleral blood vessels was diagnosed by histopathologic assessment and confirmed by immunohistochemical labelling. Despite extensive and repeated diagnostic testing over many months, a putative primary site was not identified until 19 months after the initial ocular signs were noted. At that time, a heart‐base mass and congestive heart failure were highly suggestive of a chemodectoma. Conclusion This comprehensive report of a NEN presumed metastatic to the choroid in a dog suggests that ocular disease can be a very early and solitary sign of NEN in the dog.