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Efficacy of long‐term topical flurbiprofen in limiting lens capsule opacities following phacoemulsification in dogs
Author(s) -
Newbold Georgina M.,
Chen Thomas,
Ward Daniel A.,
Hendrix Diane V. H.
Publication year - 2020
Publication title -
veterinary ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.594
H-Index - 50
eISSN - 1463-5224
pISSN - 1463-5216
DOI - 10.1111/vop.12784
Subject(s) - phacoemulsification , medicine , flurbiprofen , artificial tears , surgery , cataract surgery , capsule , cataracts , lens capsule , tears , ophthalmology , anesthesia , intraocular lens , visual acuity , botany , biology
Objective To assess lens capsule opacity (LCO) following phacoemulsification in dogs receiving long‐term topical ophthalmic flurbiprofen sodium 0.03%. Animal studied Twenty‐five client owned dogs undergoing phacoemulsification surgery for either diabetic or nondiabetic cataracts. Methods Prospective, randomized, masked clinical study assessing two groups of dogs for twelve months following phacoemulsification. All dogs underwent a complete eye examination and were photographed at each visit, beginning three weeks post‐surgery, and repeated at 2, 3, 6, and 12 months post‐surgery. Post‐operative treatment protocols were similar for both groups, except that Group F received topical flurbiprofen once daily for 12 months and Group A received artificial tears once daily for 12 months. Digital photographs were analyzed for LCO using a subjective grading scale (0‐4). The change in capsular opacities from 3 weeks to 12 months post‐surgery was evaluated for each dog, and the groups were compared. Results There were 25 dogs evaluated post‐phacoemulsification at each designated time point of the study. There were 12 dogs in Group A and 13 dogs in Group F. There was no significant statistical difference in LCO score between Groups A and F at baseline (3 weeks post‐surgery), 6 months post‐surgery, or 12 months post‐surgery. Scores did not change significantly from baseline to 12 months within or between groups. Conclusions Topical ophthalmic flurbiprofen sodium 0.03% solution applied once daily for 12 months following phacoemulsification does not appear to lead to a decrease in LCO formation as compared to artificial tears control.