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Effect of sedation with butorphanol on variables pertaining to the ophthalmic examination in dogs
Author(s) -
Douet JeanYves,
Regnier Alain,
Dongay Agnès,
Jugant Sophie,
Jourdan Géraldine,
Concordet Didier
Publication year - 2018
Publication title -
veterinary ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.594
H-Index - 50
eISSN - 1463-5224
pISSN - 1463-5216
DOI - 10.1111/vop.12530
Subject(s) - butorphanol , corneal reflex , nictitating membrane , sedation , medicine , anesthesia , mydriasis , reflex , analysis of variance , classical conditioning , conditioning , statistics , mathematics
Objective To evaluate whether sedation with intramuscular butorphanol can interfere with different variables of the ocular examination in dogs. Animals Twenty‐two beagles without ophthalmic abnormalities. Procedures Each dog was examined 20 min prior to and again just before administration of butorphanol to establish baseline data. The globe and nictitating membrane position was evaluated, and the following were recorded: menace response, dazzle reflex, corneal blink reflex, phenol red thread tear test ( PRT ), Schirmer tear test‐1 ( STT ‐1), pupil size ( PS ) measurement, and rebound tonometry. Then, butorphanol was injected intramuscularly at a dose of 0.2 mg/kg and these procedures were repeated 10, 20, 30, and 45 min postadministration. A sedation score graded 0 to 3 was also established at these time points. Statistical analyses were performed on quantitative data using ANOVA. Results The sedative effect was not associated with any changes in globe and nictitating membrane position; did not affect the results of the menace response, dazzle reflex, and corneal blink reflex; and had no significant effect on PRT values. However, butorphanol administration was associated with a statistically significant decrease in STT ‐1 and PS values ( P < 0.005), and a statistically significant increase in IOP ( P < 0.05). All these variations remained in the range of normal values. Conclusions and Clinical Relevance Butorphanol administered intramuscularly at 0.2 mg/kg provided a degree of sedation allowing eye examination, but was found to interfere with STT ‐1, PS , and IOP values among the diagnostic tests studied. However, these values remained within normal limits.