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Orbital invasive squamous cell carcinoma with adnexal involvement clinically mimicking feline restrictive orbital myofibroblastic sarcoma: 19 cases (1990‐2016)
Author(s) -
Diehl Kathryn A.,
Pryor Silvia G.,
Teixeira Leandro B. C.
Publication year - 2018
Publication title -
veterinary ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.594
H-Index - 50
eISSN - 1463-5224
pISSN - 1463-5216
DOI - 10.1111/vop.12506
Subject(s) - eyelid , exophthalmos , medicine , orbit (dynamics) , differential diagnosis , eye neoplasm , dermatology , pathology , surgery , engineering , aerospace engineering
Objective To describe the clinical presentations of patients diagnosed with ocular adnexal or orbital squamous cell carcinoma ( SCC ), which possess features similar to feline restrictive orbital myofibroblastic sarcoma ( FROMS ). Procedures A retrospective review of adnexal and/or orbital SCC was performed. Cases were collected from the University of Georgia College of Veterinary Medicine and the Comparative Ocular Pathology Laboratory of Wisconsin ( COPLOW ) (1990‐2016). Data included signalment, ophthalmic clinical signs, nonophthalmic history and clinical signs, clinician suspicion of FROMS , advanced imaging results, and subsequent histopathologic diagnosis. FROMS cases from the COPLOW over the same time span were reviewed and compared statistically to the SCC cases with a significance threshold of 0.05. Results Nineteen cases (20 eyes) were identified with adnexal SCC with features similar to FROMS , including keratitis and eyelid/third eyelid restriction and/or thickening. There were no statistically significant differences between clinical findings in the SCC cases and the identified and compared FROMS cases (57 cases; 67 eyes), except for exophthalmos and/or resistance to retropulsion, which was less common in SCC cases (20%) than in FROMS cases (47.8%) ( P = 0.027); and clinical or imaged presence of an overt eyelid or orbital mass, which was more common in the SCC cases (30%) than in the FROMS cases (4.5%) ( P = 0.0010). Conclusions SCC with adnexal involvement has many features similar to FROMS . In addition to FROMS , SCC should be considered a differential diagnosis in cats with restrictive adnexal or orbital signs and corneal changes.