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Effect of topical 1% cyclopentolate hydrochloride on tear production, pupil size, and intraocular pressure in healthy Beagles
Author(s) -
Costa Daniel,
Leiva Marta,
Coyo Natàlia,
Laguna Fernando,
Ríos Jose,
Peña Gimenez Maria Teresa
Publication year - 2016
Publication title -
veterinary ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.594
H-Index - 50
eISSN - 1463-5224
pISSN - 1463-5216
DOI - 10.1111/vop.12323
Subject(s) - cyclopentolate , beagle , medicine , pupil size , pupillary response , intraocular pressure , ophthalmology , pupil , eye drop , anesthesia , psychology , neuroscience
Objective The objective of the study was to evaluate the effect of topical 1% cyclopentolate hydrochloride ( CH ) on tear production ( TP ), pupil size ( PS ), and intraocular pressure ( IOP ) in dogs. Animal studied Fifteen healthy beagle dogs from the UAB research‐teaching colony. Procedure Dogs without ocular diseases were included. Each animal received one drop of 1% CH ophthalmic solution in a randomly selected eye. TP , PS , and IOP were evaluated by means of STT ‐1, static pupillometry, and rebound tonometry, respectively. Evaluations were performed before drug instillation and at 0.5, 1, 2, 4, 8, 12, 24, 30, 36, 48, 54, 60, 72, 84, and 96 h postinstillation. Examinations took place in a room with fixed light intensity (40–55 lux). Statistical analysis was performed by means of generalized estimating equations for the effect on STT ‐1, pupil size, and IOP over time. Results After unilateral application of 1% CH , significant pupillary dilation started at 30 min, reached its maximum at 12 h, and returned to pre‐instillation size after 72 h. No significant effects were found on TP or IOP , at any time. No effects were observed in the untreated eye on any of the parameters evaluated. Conclusion Cyclopentolate hydrochloride could be considered a therapeutic alternative when use of a cycloplegic drug is needed and effects on tear production and IOP are unwanted.