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Effects of oral administration of trimethoprim‐sulfamethoxazole on tear production in clinically normal guinea pigs
Author(s) -
Asadi Faezeh,
Rajaei Seyed Mehdi,
Golabdar Salar
Publication year - 2016
Publication title -
veterinary ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.594
H-Index - 50
eISSN - 1463-5224
pISSN - 1463-5216
DOI - 10.1111/vop.12317
Subject(s) - medicine , trimethoprim , placebo , sulfamethoxazole , oral administration , antibiotics , biology , pathology , alternative medicine , microbiology and biotechnology
Objective To determine the effects of short‐term oral administration of trimethoprim‐sulfamethoxazole on tear production in clinically normal guinea pigs. Animal studied Thirty‐two healthy adult Abyssinian guinea pigs were used in this study. Procedure One day before the start of the trial, the pretreatment baseline phenol red thread test ( PRTT ) values were recorded. Sixteen guinea pigs in the treated group received 25 mg/kg trimethoprim‐sulfamethoxazole orally twice a day for 14 days. The other sixteen guinea pigs were used as untreated controls and received a placebo during the study. All the ophthalmic tests were performed without chemical restraint. PRTT values were evaluated in both eyes of all the guinea pigs using a commercial PRTT strip of a single lot number on days 0 (baseline), 15, and 21 after starting the trial. Results The pretreatment baseline mean ± SD PRTT values for the treatment and control groups were 11.12 ± 3.82 mm/15 s and 11.93 ± 2.73 mm/15 s, respectively. After 14 days of drug administration, the mean ± SD PRTT values for the treatment and control groups were 10.87 ± 3.11 mm/15 s and 13.00 ± 2.47 mm/15 s, respectively. On Day 21, the mean ± SD PRTT values for the treatment and control groups were 12.62 ± 4.05 mm/15 s and 12.87 ± 2.99 mm/15 s, respectively. Significant decreases in the PRTT values, compared with the pretreatment baseline values, were not observed in the treatment group on Day 15 ( P = 0.14) and Day 21 ( P = 0.31). Conclusions Trimethoprim‐sulfamethoxazole did not decrease tear production in the guinea pigs in this study.