Premium
Golden retriever cystic uveal disease: a longitudinal study of iridociliary cysts, pigmentary uveitis, and pigmentary/cystic glaucoma over a decade in western Canada
Author(s) -
Holly Vanessa L.,
Sandmeyer Lynne S.,
Bauer Bianca S.,
Verges Linda,
Grahn Bruce H.
Publication year - 2016
Publication title -
veterinary ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.594
H-Index - 50
eISSN - 1463-5224
pISSN - 1463-5216
DOI - 10.1111/vop.12293
Subject(s) - medicine , incidence (geometry) , penetrance , glaucoma , uveitis , ophthalmology , biology , biochemistry , physics , optics , gene , phenotype
Objectives To determine the incidence of iridociliary cysts, pigmentary uveitis ( PU )/pigmentary cystic glaucoma ( PCG ) in golden retriever dogs in western Canada, the progression of iridociliary cysts to PU / PCG , and a mode of inheritance for this disorder. Animal studied A total of 830 golden retriever dogs from Alberta, Saskatchewan, and Manitoba from 2004 to 2014 were studied. Procedure Data were compiled from Canine Eye Registry Foundation ( CERF ) or Orthopedic Foundation for Animals ( OFA ) records ( n = 630) and clinical consultations ( n = 200) for a retrospective assessment of iridociliary cysts, PU , and PCG . Results Total incidence of iridociliary cysts and PU from CERF / OFA data were 4.8% ( n = 30/630) and 5.9% ( n = 37/630), respectively. Incidence of PU increased with ages >4 years (12.7%, n = 32/251). Dogs diagnosed with thin‐walled, attached iridociliary cysts had a high risk of being diagnosed with PU or PCG upon re‐examination (56.5%, n = 13/23). No dogs diagnosed with thick‐walled, anterior chamber cysts ( n = 7) developed PU or PCG within the time frame of the study. Data from clinical consultations confirmed that PU carried a poor prognosis for the affected eyes as 44.9% ( n = 22/49) of dogs progressed to PCG . PU ‐ and PCG ‐affected dogs followed a familial pattern and there was an association with thin‐walled iridociliary cysts. Pedigree analysis suggested an autosomal dominant mode of inheritance with partial penetrance. Conclusions Thin‐walled iridociliary cysts are associated with PU and PCG . All breeding golden retriever dogs should be examined annually by an ophthalmologist. The incidence of this disorder is higher in western Canada than previous reports in North America.