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Clinical effect of four different ointment bases on healthy cat eyes
Author(s) -
Eördögh Réka,
Schwendenwein Ilse,
Tichy Alexander,
Loncaric Igor,
Nell Barbara
Publication year - 2016
Publication title -
veterinary ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.594
H-Index - 50
eISSN - 1463-5224
pISSN - 1463-5216
DOI - 10.1111/vop.12279
Subject(s) - medicine , cats , cytology , ophthalmology , pathology
Objective To describe the effects of long‐term treatment with four different eye ointment bases ( OB s) in cats. Animals studied Ten healthy cats. Procedures The study was performed in two periods. Four different OB s were tested. Hundred grams of OB contained the following: OB ‐A: 35.17 g liquid paraffin (lp), 64.83 g white petrolatum (wp); OB ‐B: 10.03 g lp, 84.95 g wp 5.02 g lanolin; OB ‐C: 18.34 g lp, 51.40 g wp, 25.00 mg KH 2 PO 4 , 57.00 mg K 2 HPO 4 , 18.90 g eucerinum anhydricum, 11.28 g water for injections; and OB ‐D: 70 g unguentum lanalcoli, 20 g lp, 10 g aqua conservans. One eye was treated, and the other served as a negative control. Cats received the OB s TID for 28 days. The two study periods were separated by a 4‐month washout phase. Samples for conjunctival impression cytology, swabs for bacteriologic and mycologic examination, and cytobrush samples for FHV ‐1 and Chlamydophila felis PCR detection were obtained. Both eyes were examined daily. Severity of ocular symptoms was scored using a modified Draize eye irritation test. A total of five eyes were treated with OB ‐A, five with OB ‐B, four with OB ‐C, and five with OB ‐D. Results Treated eyes had significantly higher clinical scores. Eyes receiving OB ‐A had the highest overall clinical score. The results of bacteriologic and mycologic examination concur with the previously published data. All samples tested were negative for FHV ‐1 and Chlamydophila felis . There was no significant difference between treated and control eyes upon cytological examination. Conclusion The application of OB s resulted in clinical symptoms in treated eyes. The long‐term use of ointments is not well tolerated in cats and may lead to ocular irritation.