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Anticoagulant rodenticide toxicity in six dogs presenting for ocular disease
Author(s) -
Griggs Angela N.,
Allbaugh Rachel A.,
Tofflemire Kyle L.,
BenShlomo Gil,
Whitley David,
Paulsen Michael E.
Publication year - 2016
Publication title -
veterinary ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.594
H-Index - 50
eISSN - 1463-5224
pISSN - 1463-5216
DOI - 10.1111/vop.12267
Subject(s) - medicine , rodenticide , exophthalmos , prothrombin time , anticoagulant , partial thromboplastin time , anesthesia , toxicity , ingestion , surgery , gastroenterology , ecology , platelet , biology
Objective To describe cases of suspected anticoagulant rodenticide toxicity manifesting with predominantly ocular signs. Materials and methods Six canine cases that presented to veterinary referral hospitals for ocular abnormalities and were diagnosed with suspected or confirmed anticoagulant rodenticide ingestion were reviewed for commonalities in presentation and outcome. Results Five dogs had unilateral ocular signs and one dog had bilateral manifestations. Signs included subconjunctival hemorrhage, exophthalmos, and commonly orbital pain without other significant physical examination findings. Prothrombin time was measured in 5 of 6 dogs and was prolonged in all. Partial thromboplastin time was measured in 4 of 6 dogs and was prolonged in all. Complete blood cell count and serum chemistry profiles demonstrated mild, if any, abnormalities. Five dogs had known anticoagulant rodenticide exposure, and rodenticide ingestion was suspected in 1 additional case based on clinical signs, clinical pathologic abnormalities, and response to treatment. Five of 6 cases were hospitalized overnight for plasma transfusions along with oral or injectable vitamin K 1 , and all dogs were treated with oral vitamin K 1 for 30 days. All dogs experienced complete resolution of clinical signs within 6 weeks of initiating treatment. Conclusions Anticoagulant rodenticide toxicity can present with predominantly ocular manifestations. Rodenticide ingestion should be considered in dogs with unilateral or bilateral subconjunctival hemorrhage, exophthalmos, and orbital pain.