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Effect of topical ophthalmic dorzolamide(2%)–timolol(0.5%) solution and ointment on intraocular pressure in normal horses
Author(s) -
Tofflemire Kyle L.,
Whitley Elizabeth M.,
Flinn Allison M.,
Dufour Valerie L.,
BenShlomo Gil,
Allbaugh Rachel A.,
Griggs Angela N.,
Peterson Chimene S.,
Whitley David R.
Publication year - 2015
Publication title -
veterinary ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.594
H-Index - 50
eISSN - 1463-5224
pISSN - 1463-5216
DOI - 10.1111/vop.12242
Subject(s) - dorzolamide , timolol , medicine , intraocular pressure , ophthalmology , horse , anesthesia , glaucoma , paleontology , biology
Objective To compare the effect of commercially available solution and compounded ointment formulations of dorzolamide(2%)–timolol(0.5%) on intraocular pressure ( IOP ) of normal horses. Animals Eighteen clinically normal horses. Procedures A randomized, masked prospective design was used with horses divided into two equal groups. One eye of each horse was selected for topical ophthalmic treatment with either 0.2 mL of dorzolamide(2%)–timolol(0.5%) solution or 0.2 g of dorzolamide(2%)–timolol(0.5%) ointment every 12 h for 5 days. The contralateral eye of horses in both groups was untreated. Rebound tonometry was performed every 6 h starting 2 days prior to and ending 2 days after the treatment period. Results The mean IOP reduction in eyes treated with the solution or ointment formulations was 13%. Untreated eyes in both groups experienced a lesser but still statistically significant reduction in IOP . The IOP values did not return to baseline within 48 h of the last treatment. Conclusions and Clinical Relevance The commercially available solution and compounded ointment formulations of ophthalmic dorzolamide(2%)–timolol(0.5%) had similar effects on IOP in normal horses. Persistent IOP reduction following cessation of treatment may indicate prolonged drug effect or acclimation of horses to tonometry.