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Porcine urinary bladder extracellular matrix grafts ( AC ell V et ® C orneal D iscs) for keratomalacia in 17 equids (2012–2013)
Author(s) -
Mancuso Laura A.,
Lassaline Mary,
Scherrer Nicole M.
Publication year - 2016
Publication title -
veterinary ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.594
H-Index - 50
eISSN - 1463-5224
pISSN - 1463-5216
DOI - 10.1111/vop.12240
Subject(s) - medicine , extracellular matrix , cytology , surgery , extracellular , pathology , biology , microbiology and biotechnology
Objective To describe the clinical course, outcomes, and complications associated with use of commercially available porcine urinary bladder extracellular matrix ( ECM ) grafts ( AC ell V et ® C orneal D iscs) in equid patients with keratomalacia, and to evaluate the efficacy of ECM grafts as a viable alternative to other biomaterials for corneal grafting in equid patients. Animals Sixteen horses and one donkey (17 eyes) with unilateral keratomalacia severe enough to warrant surgical repair between A ugust 2012 and S eptember 2013. Procedure Retrospective medical record review to identify equid patients meeting inclusion criteria of (i) diagnosis with keratomalacia severe enough to warrant surgical repair and (ii) surgical repair with an extracellular matrix graft. Results Eleven geldings, four mares, and two colts met inclusion criteria. Patients averaged 9 years of age. Twelve of 17 eyes (71%) were considered infected based on either corneal cytology (10/17, or 59%) or corneal culture (12/17, or 71%) positive for bacteria (8/17, or 47%) or fungi (9/17, or 53%). At the time topical medications were discontinued, 16 eyes (94%) were visual. One operated eye ruptured 5 days postoperatively and was enucleated. Keratouveitis developed in 14/14 eyes that underwent regular examinations approximately 2 weeks postoperatively which responded to systemic nonsteroidal anti‐inflammatory drug therapy. Conclusions Extracellular matrix grafts may be a viable alternative to other biomaterials for corneal grafting in equids. Advantages include commercial availability and shelf storage.