Premium
Effect of tiletamine–zolazepam on the intraocular pressure of the dog
Author(s) -
Jang Min,
Park Sangwan,
Son Wongyun,
Jo Sangmin,
Hwang Hyeshin,
Seo Kangmoon,
Lee Inhyung
Publication year - 2015
Publication title -
veterinary ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.594
H-Index - 50
eISSN - 1463-5224
pISSN - 1463-5216
DOI - 10.1111/vop.12237
Subject(s) - medicine , intraocular pressure , anesthesia , crossover study , ophthalmology , alternative medicine , pathology , placebo
Objective To determine the effect of tiletamine–zolazepam ( TZ ) on canine intraocular pressure ( IOP ). Animals studied Six healthy dogs without ocular abnormalities were used in this study. Procedures The study was carried out as a crossover experimental trial with a 7‐day interval between treatments. TZ combination was administered intravenously ( IV ) at a dose of 5, 10, and 20 mg/kg ( TZ 5, TZ 10, and TZ 20, respectively). Following preanesthetic baseline readings of IOP , each dog received IV TZ and then the IOP values were measured every 10 min for 40 min in all treatments. Results The baseline IOP values (mean ± standard deviation) for TZ 5, TZ 10, and TZ 20 were 12.7 ± 0.8, 14.4 ± 1.2, and 15.3 ± 1.7 mmHg, and each IOP changed to 11.1 ± 1.1, 13.1 ± 1.4 and 13.5 ± 1.7 mmHg after intravenous administration of each TZ treatment, respectively. However, there were no statistical differences between baseline and post‐treatment values. Conclusions The TZ combination had no clinically significant effect on IOP of the dog. This could be an option for induction or surgical procedures in dogs with ophthalmic problems when an increase in IOP is undesirable.