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Effect of intravenous administration of romifidine on intraocular pressure in clinically normal horses
Author(s) -
Marzok Mohamed A.,
Elkhodery Sabry A.,
Oheida Aiman H.
Publication year - 2014
Publication title -
veterinary ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.594
H-Index - 50
eISSN - 1463-5224
pISSN - 1463-5216
DOI - 10.1111/vop.12181
Subject(s) - medicine , intraocular pressure , saline , anesthesia , ophthalmology
Objective To evaluate the effect of intravenous administration of romifidine on the intraocular pressure ( IOP ) in horses. Animals studied Twenty‐four horses with no ocular abnormalities. Procedure Horses were randomly assigned into two equal groups (treatment and control). All horses in the treatment group received an intravenous ( IV ) injection of romifidine (40 μg/kg). The horses in the control group were administrated an intravenous injection of 0.9% saline (0.4 mL/100 kg). In both groups, the IOP values were measured immediately (T 0 ) pre‐administration and at 5 (T 5 ), 15 (T 15 ), 30 (T 30 ), 45 (T 45 ), 60 (T 60 ), 90 (T 90 ), and 120 (T 120 ) min after drug administration. Results The pre‐treatment values (T 0 ) of IOP for right and left eyes were 24.25 ± 3.5 and 25.16 ± 3.4 mmHg, respectively. A significant decrease in IOP values was observed in both right and left eyes of the horses in treatment group at T 5 , T 15 , T 30 , T 45 , T 60 , and T 90 in comparison with the baseline values ( P < 0.05). The lowest level of IOP in romifidine‐treated groups was recorded at T 45 for the right and left eyes (10.25 ± 2.3 and 11.25 ± 3.5 mmHg, respectively). Conclusion Romifidine significantly decreased IOP in clinically normal horses and may be used safely for surgery or diagnostic ocular procedures in horses when specific control of IOP is required.