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Intraocular pressure, specular microscopy, and prostaglandin E 2 concentration in dogs with mature and hypermature cataract
Author(s) -
Renzo Roberta,
Ribeiro Alexandre P.,
Silva Miguel L.,
Silva Germana Alegro,
Ortencio Kethye P.,
Barros Sobrinho Alexandre A. F.,
Wilson Patriarca Mineo Tiago,
Laus José Luiz
Publication year - 2014
Publication title -
veterinary ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.594
H-Index - 50
eISSN - 1463-5224
pISSN - 1463-5216
DOI - 10.1111/vop.12144
Subject(s) - intraocular pressure , prostaglandin , ophthalmology , aqueous humor , ocular hypertension , chemistry , latanoprost , medicine , endocrinology
Abstract This study aimed to evaluate and correlate intraocular pressure ( IOP ), endothelial cell density ( CD ), and hexagonality ( HEX ), and the aqueous humor prostaglandin E 2 ( PGE 2 ) concentration in dogs with mature ( MG , n = 8) and hypermature ( HG , n = 8) cataracts. Eight laboratory beagles with no ocular abnormalities were included as a control group ( CG ). The IOP was measured using a digital applanation tonometer. Noncontact specular microscopy was used to evaluate CD and HEX . Samples of aqueous humor were used to determine prostaglandin E 2 concentration using enzyme‐linked immunoassay. Data were compared by anova and B onferroni's multiple comparison test, and possible correlations among the PGE 2 aqueous concentration and corneal endothelium cell parameters were assessed by P erson′s test ( P < 0.05). Average values of IOP ( P = 0.45) and CD ( P = 0.39) were not significantly different between MG , HM , and CG . Average values of HEX were lower, and PGE 2 concentration was increased in the MG and HG in comparison with CG ( P < 0.05); however, such parameters did not change significantly between MG and HG ( P > 0.05). PGE 2 values did not correlate with IOP , CD , and HEX in any group ( P > 0.05). Although there were a small number of dogs studied, our results demonstrated that cataract progression from mature to hypermature did not have a significant change in PGE 2 aqueous concentration, IOP , corneal endothelial cell count, or morphology. In addition, PGE 2 concentration was not correlated with parameters of the corneal endothelium or IOP in dogs with mature or hypermature cataracts.