Premium
Intraocular and periocular lymphoma in dogs and cats: a retrospective review of 21 cases (2001–2012)
Author(s) -
OtaKuroki Juri,
Ragsdale John M.,
Bawa Bhupinder,
Wakamatsu Nobuko,
Kuroki Keiichi
Publication year - 2014
Publication title -
veterinary ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.594
H-Index - 50
eISSN - 1463-5224
pISSN - 1463-5216
DOI - 10.1111/vop.12106
Subject(s) - lymphoma , intraocular lymphoma , cats , medicine , pathology , b cell lymphoma , eye neoplasm
Objective To immunologically phenotype and histologically classify canine and feline intraocular and periocular lymphomas. Methods The databases of four veterinary medical diagnostic laboratories were searched to identify cases of intraocular or periocular lymphoma in dogs and cats between 2001 and 2012. Hematoxylin and eosin ( H&E ) stained slides were reviewed for confirmation and classification of lymphoma, and immunohistochemistry for CD 3 ( T ‐cell marker) and CD 79a and/or CD 20 ( B ‐cell markers) was examined to determine the lineage of the neoplastic lymphocytes. Results Six canine and 15 feline cases of ocular lymphoma were identified. In the canine cases, there were three intraocular and three periocular lymphomas where two intraocular and one periocular lymphomas were B‐cell, one of each intraocular and periocular lymphomas were T ‐cell and one periocular lymphoma was nonreactive with CD 3, CD 79a or CD 20. In the feline cases, there were six intraocular and nine periocular lymphomas where five intraocular and six periocular lymphomas were B‐cell, and one intraocular and three periocular lymphomas were T ‐cell. Only one canine case had concurrent generalized lymphadenopathy, only one canine conjunctival lymphoma had simultaneous cutaneous lymphoma, and only one feline case had bilateral ocular involvement when they were diagnosed. Conclusion Canine and feline intraocular and periocular lymphomas are often of B ‐cell phenotype. Although in general terms lymphoma is not considered a primary tumor when it occurs in or adjacent to the globe, these tumors frequently first become evident in the globe and/or periocular area. An accurate early diagnostic approach is crucial for the patient's quality of life because B ‐cell lymphomas are generally more amenable to chemotherapy than T ‐cell lymphomas.