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Progression of pectinate ligament dysplasia over time in two populations of Flat‐Coated Retrievers
Author(s) -
Pearl Rose,
Gould David,
Spiess Bernhard
Publication year - 2015
Publication title -
veterinary ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.594
H-Index - 50
eISSN - 1463-5224
pISSN - 1463-5216
DOI - 10.1111/vop.12098
Subject(s) - gonioscopy , ophthalmology , medicine , glaucoma , dysplasia , ligament , surgery , pathology
Objective Two of the authors ( DG , BS ) independently observed that a number of Flat‐Coated Retrievers ( FCR s) previously unaffected by pectinate ligament dysplasia ( PLD ) appeared to develop the condition later in life. This study was instigated to investigate progression of PLD within individual dogs over time. Animals studied Flat‐Coated Retrievers that had previously undergone gonioscopy under the UK / ECVO hereditary eye schemes were included in the study. Procedure A second gonioscopic examination was performed 1.92–12.58 years later (mean 6, median 5.75 years) and the results compared. 39 FCR (17 males, 22 females) in the UK and 57 FCR (27 males, 30 females) in Switzerland were included. Slit‐lamp biomicroscopy, indirect ophthalmoscopy, and gonioscopy were performed in all dogs. Gonioscopy allowed classification as either unaffected or affected; percentage of the iridocorneal drainage angle ( ICA ) affected by PLD was determined, before calculating progression observed as mild, moderate, or severe. Results 39 of 96 (40.6%) dogs demonstrated progression of PLD ( P < 0.0001). Of these, 13 of 96 (13.5%) were classified as mild progression (from either unaffected to 10–20% or 10–20% to 20–90% ICA affected). Progression was more extensive in 26 of 96 (27.1%) dogs ( P < 0.0001), of which 12 of 96 (12.5%) went from unaffected to severe PLD of >90% ICA affected, consistent with a high risk of glaucoma. Conclusions To the authors' knowledge, this is the first report describing progression of PLD in individual dogs over time, in a breed affected by primary, angle closure glaucoma.