Canine multifocal retinopathy caused by a BEST 1 mutation in a B oerboel

A 7‐month‐old male intact B oerboel presented to the C ummings S chool of V eterinary M edicine at T ufts U niversity for the evaluation of ocular discharge. Bilateral multifocal serous retinal detachments were noted on fundus examination as an incidental finding. Genetic testing confirmed the dog to be homozygous for a mutation in the BEST 1 gene, where a C 73 T/R 25 X change results in premature termination codon. Further testing, including electroretinography and optical coherence tomography ( OCT ), demonstrated that there was no evidence of retinal photoreceptor dysfunction and confirmed that observed lesions were characteristic of canine multifocal retinopathy. No progression of the lesions was noted 3 months after the initial examination. To the authors’ knowledge, this is the first report of canine multifocal retinopathy in the B oerboel breed.