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Canine multifocal retinopathy caused by a BEST 1 mutation in a B oerboel
Author(s) -
Gornik Kara R.,
Pirie Christopher G.,
Duker Jay S.,
Boudrieau Randy J.
Publication year - 2014
Publication title -
veterinary ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.594
H-Index - 50
eISSN - 1463-5224
pISSN - 1463-5216
DOI - 10.1111/vop.12095
Subject(s) - medicine , fundus (uterus) , ophthalmology , electroretinography , retinopathy , retinal , optical coherence tomography , pathology , endocrinology , diabetes mellitus
A 7‐month‐old male intact B oerboel presented to the C ummings S chool of V eterinary M edicine at T ufts U niversity for the evaluation of ocular discharge. Bilateral multifocal serous retinal detachments were noted on fundus examination as an incidental finding. Genetic testing confirmed the dog to be homozygous for a mutation in the BEST 1 gene, where a C 73 T/R 25 X change results in premature termination codon. Further testing, including electroretinography and optical coherence tomography ( OCT ), demonstrated that there was no evidence of retinal photoreceptor dysfunction and confirmed that observed lesions were characteristic of canine multifocal retinopathy. No progression of the lesions was noted 3 months after the initial examination. To the authors’ knowledge, this is the first report of canine multifocal retinopathy in the B oerboel breed.