z-logo
Premium
Analysis of a deletion in the nephronophthisis 4 gene in different dog breeds
Author(s) -
Palánová Anna,
Schröffelová Daniela,
Přibáňová Michaela,
Dvořáková Věra,
Stratil Antonín
Publication year - 2014
Publication title -
veterinary ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.594
H-Index - 50
eISSN - 1463-5224
pISSN - 1463-5216
DOI - 10.1111/vop.12092
Subject(s) - nephronophthisis , genetics , gene , biology , mutation , phenotype
Cone‐rod dystrophy is a progressive inherited retinal degenerative disorder that occurs in humans and dogs. The deletion in the nephronophthisis 4 ( NPHP 4 ) gene was established as a causative mutation in standard wire‐haired Dachshunds. We analyzed all varieties of Dachshunds from the Czech Republic and five other dog breeds and found that the deletion in the NPHP 4 (in heterozygous state) is present not only in standard‐, but also in miniature wire‐haired Dachshunds, but not in other varieties of Dachshunds or in other breeds.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here