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Positive immunostaining for feline infectious peritonitis ( FIP ) in a Sphinx cat with cutaneous lesions and bilateral panuveitis
Author(s) -
Bauer Bianca S.,
Kerr Moira E.,
Sandmeyer Lynne S.,
Grahn Bruce H.
Publication year - 2013
Publication title -
veterinary ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.594
H-Index - 50
eISSN - 1463-5224
pISSN - 1463-5216
DOI - 10.1111/vop.12044
Subject(s) - feline infectious peritonitis , pathology , medicine , cats , immunohistochemistry , dermis , skin biopsy , immunostaining , biopsy , infectious disease (medical specialty) , disease , covid-19
Feline infectious peritonitis ( FIP ) is a common, fatal, systemic disease of cats. This case report describes the antemortem diagnosis of FIP in a 2‐year‐old spayed female Sphinx cat that presented with a bilateral panuveitis and multiple papular cutaneous lesions. Histopathologically, the skin lesions were characterized by perivascular infiltrates of macrophages, neutrophils, with fewer plasma cells, mast cells, and small lymphocytes in the mid‐ to deep dermis. Immunohistochemistry for intracellular feline coronavirus (FeCoV) antigen demonstrated positive staining in dermal macrophages providing an antemortem diagnosis of a moderate, nodular to diffuse, pyogranulomatous perivascular dermatitis due to FIP infection. Obtaining an antemortem diagnosis of FIP can be a challenge and cutaneous lesions are rare in the disease. Recognition and biopsy of any cutaneous lesions in cats with panuveitis and suspected FIP can help establish an antemortem diagnosis of the disease.