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Unilateral intraocular mastocytosis and anterior uveitis in a dog with subcutaneous mast cell tumors
Author(s) -
Boostrom Brendan O.,
Good Kathryn L.,
Maggs David J.,
Rebhun Robert B.,
Johns Jennifer L.,
Kent Michael S.
Publication year - 2014
Publication title -
veterinary ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.594
H-Index - 50
eISSN - 1463-5224
pISSN - 1463-5216
DOI - 10.1111/vop.12041
Subject(s) - medicine , mast cell , uveitis , cytology , cutaneous mastocytosis , pathology , surgery , ophthalmology , systemic mastocytosis , immunology
Abstract A 9‐year‐old male castrated S cottish terrier was referred to the Radiation Oncology Service at the W illiam R . P ritchard V eterinary M edical T eaching H ospital for palliative radiation therapy of an incompletely excised, recurrent subcutaneous mast cell tumor ( MCT ) located over the right scapula, and surgical removal of a perianal MCT. Three weeks after initial presentation and prior to the fifth radiation treatment, the patient was presented with cloudiness of the left eye of 3–7 days duration. Ophthalmic consultation revealed 3+ aqueous flare with a dependent, swirling component filling approximately one‐third of the anterior chamber. Aqueocentesis was performed under general anesthesia. Cytology revealed mast cells with highly atypical morphology and considered most consistent with neoplasia. The patient died 7 months after pathologic diagnosis of MCT on the right shoulder and 2 months after the cytologic diagnosis of malignant mast cells in the left anterior chamber. To the authors' knowledge, this is the first report of intraocular involvement in a mammal with MCTs, described here as intraocular mastocytosis.