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Ex vivo evaluation of the efficacy of canine fresh‐frozen plasma thawed using a microwave plasma defroster
Author(s) -
Turner Matthew Alfred,
Rahilly Louisa Jane,
Katheryn O'Marra Shana
Publication year - 2018
Publication title -
journal of veterinary emergency and critical care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.886
H-Index - 47
eISSN - 1476-4431
pISSN - 1479-3261
DOI - 10.1111/vec.12768
Subject(s) - fresh frozen plasma , medicine , fibrinogen , partial thromboplastin time , clotting factor , von willebrand factor , prothrombin time , coagulopathy , thromboplastin , prothrombin complex concentrate , anesthesia , platelet , coagulation , warfarin , atrial fibrillation
Background Commercial microwave plasma defrosters (MPDs) are used globally in human medicine to safely thaw fresh‐frozen plasma (FFP), but this technology has never been tested in a veterinary setting. This study was undertaken to assess the efficacy of a commercial MPD for the rapid thawing of canine FFP. Study Design Twenty‐three units (twelve 120 mL and eleven 240 mL) of canine FFP were thawed using an MPD. Time‐to‐thaw and pre‐ and postthawing temperatures of the units were measured. Clotting factor activities (factors II, V, VII, VIII, IX, X, and von Willebrand factor), fibrinogen concentrations, prothrombin times, and activated partial thromboplastin times were measured. Key Findings The evaluated MPD effectively thaws plasma quickly for both 120 mL units (2.7 ± 0.08 min) and 240 mL units (3.9 ± 0.15 min) while maintaining clinically relevant activities of clotting factors and fibrinogen concentration. While some measurements of factor VIII activity fell below the reference interval, none fell below 40%. One 240 mL unit had von Willebrand factor activity <70%. There was no evidence of excessively heated plasma to indicate a safety concern. Significance The MPD evaluated in this study provides a useful means to rapidly thaw canine FFP for correction of factor‐deficient coagulopathy.

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