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Use of 20% intravenous lipid emulsion for the treatment of loperamide toxicosis in a Collie homozygous for the ABCB1‐1∆ mutation
Author(s) -
Long Whitney M.,
Sinnott Virginia B.,
Bracker Kiko,
Thomas Danielle
Publication year - 2016
Publication title -
journal of veterinary emergency and critical care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.886
H-Index - 47
eISSN - 1476-4431
pISSN - 1479-3261
DOI - 10.1111/vec.12562
Subject(s) - loperamide , medicine , diarrhea , bolus (digestion) , anesthesia , ataxia , pharmacology , gastroenterology , psychiatry
Abstract Objective To describe the successful treatment of loperamide toxicosis in a dog using intravenous lipid emulsion (ILE). Case Summary An 8‐month‐old male neutered Rough Collie weighing 20.0 kg was given a total dose of 0.75 mg/kg loperamide over 3 days as treatment for diarrhea. The dog was subsequently evaluated for signs of dull mentation, anxiety, ptyalism and ataxia, thought to be a result of loperamide intoxication. The dog was treated with a 1.5 mL/kg IV bolus of 20% ILE solution followed by 0.25 mL/kg/min of the same solution for 2 hours. The dog's mentation improved rapidly following ILE infusion, and he was neurologically normal 3 hours after initiation of ILE treatment. The dog was subsequently found to be homozygous for the ATP‐binding cassette (ABC) transporter gene (ABCB1‐1∆) mutation. There were no adverse effects noted during or following ILE infusion. New or Unique Information Provided ILE was successful in the treatment of loperamide toxicosis in a Collie with the ABCB1‐1∆ mutation. ILE may be of benefit for treatment of other intoxications in dogs with ABCB1‐1Δ mutations.