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Treatment of ibuprofen toxicity with serial charcoal hemoperfusion and hemodialysis in a dog
Author(s) -
Tauk Barbara S.,
Foster Jonathan D.
Publication year - 2016
Publication title -
journal of veterinary emergency and critical care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.886
H-Index - 47
eISSN - 1476-4431
pISSN - 1479-3261
DOI - 10.1111/vec.12544
Subject(s) - hemoperfusion , medicine , hemodialysis , ibuprofen , activated charcoal , extracorporeal , charcoal , anesthesia , toxicity , surgery , pharmacology , chemistry , materials science , organic chemistry , adsorption , metallurgy
Objective To describe the efficacy of serial charcoal hemoperfusion and hemodialysis in removing ibuprofen from a dog with severe clinical signs of toxicity. Case Summary A dog ingested a minimum of 2,200 mg/kg of ibuprofen resulting in progressive neurologic dysfunction that progressed to a comatose state by the time of presentation. Extracorporeal charcoal hemoperfusion coupled serially with hemodialysis was performed to remove ibuprofen from this patient. Serial charcoal hemoperfusion and hemodialysis therapy resulted in complete reversal of the neurologic dysfunction in this dog. No evidence of acute kidney or hepatic injury was observed. Serum ibuprofen concentrations confirmed the efficacy of this treatment. New Information Provided This report details the technique for extracorporeal extraction of ibuprofen, a methodology that could be employed for other toxicities due to substances with similar pharmacokinetics. Complications and limitations (eg, saturation of the charcoal cartridge) of the therapy are discussed.