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Cryopreserved platelet concentrate transfusions in 43 dogs: a retrospective study (2007–2013)
Author(s) -
Ng Zenithson Y.,
Stokes Jennifer E.,
Alvarez Lucia,
Bartges Joe W.
Publication year - 2016
Publication title -
journal of veterinary emergency and critical care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.886
H-Index - 47
eISSN - 1476-4431
pISSN - 1479-3261
DOI - 10.1111/vec.12503
Subject(s) - medicine , hematocrit , retrospective cohort study , platelet , surgery , platelet transfusion , adverse effect , population , medical record , environmental health
Objective To clinically characterize a group of thrombocytopenic dogs that received cryopreserved platelet concentrate (cPC) transfusion, assess efficacy of cPC treatment in improving patient outcome, and compare treated dogs to a control population of thrombocytopenic dogs that did not receive cPC transfusions. Design Retrospective study. Setting University teaching hospital. Animals Eighty‐six client‐owned dogs (43 in treatment group, 43 in control group). Interventions None. Measurements and Main Results Medical records of thrombocytopenic dogs that received cPC transfusions and those of thrombocytopenic dogs that did not receive cPC (control population) from January 2007 through March 2013 were reviewed. Dogs receiving cPC were statistically more likely than controls to have a platelet trigger for cPC transfusion ( P = 0.01), lower platelet count ( P = 0.009) and hematocrit at presentation ( P = 0.001), and lower hematocrit after cPC ( P = 0.02). Although there was a statistically significant increase in platelet count from pre‐ to post‐cPC transfusion ( P = 0.002), cPC was not found to be effective in improving clinical bleeding or increasing survival compared to the control group. No other characteristics were statistically different between groups. No dogs receiving cPC had an acute transfusion reaction during hospitalization. Conclusions In the population described in this study, cPC was not found to increase survival, but was well tolerated. Controlled, prospective studies are necessary to determine indications for and efficacy of cPC transfusions.