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Thromboelastographic evidence of inhibition of fibrinolysis after ε‐aminocaproic acid administration in a dog with suspected acute traumatic coagulopathy
Author(s) -
Yoo Seung H.,
Venn Emilee,
Sullivan Lauren A.,
Olver Christine S.
Publication year - 2016
Publication title -
journal of veterinary emergency and critical care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.886
H-Index - 47
eISSN - 1476-4431
pISSN - 1479-3261
DOI - 10.1111/vec.12467
Subject(s) - medicine , coagulopathy , fibrinolysis , aminocaproic acid , antifibrinolytic , tranexamic acid , thromboelastometry , anesthesia , surgery , blood loss
Objective To describe the thromboelastographic changes in fibrinolysis with ε‐aminocaproic acid treatment in a dog with suspected acute traumatic coagulopathy. Case Summary A 9‐year‐old female spayed Airedale Terrier was presented with multiple injuries consistent with motor vehicle trauma. After surgical repair of a diaphragmatic hernia and minor laceration of the right cranial lung lobe, the dog continued to produce copious volumes of hemorrhagic fluid from the thoracic cavity despite multiple plasma transfusions, autotransfusions, and failure to locate a definitive source of bleeding during 2 separate surgeries. ε‐Aminocaproic acid treatment was initiated and was associated with rapid clinical improvement and diminished fibrinolysis based on a modified plasma‐based thromboelastogram. New or Unique Information Provided This report describes thromboelastographic evidence of inhibition of fibrinolysis after ε‐aminocaproic acid administration in a dog with suspected acute traumatic coagulopathy. Thromboelastrography may be useful in monitoring therapy with antifibrinolytic drugs.