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Evaluation of the relationship between clinical variables and thromboelastographic findings in dogs with protein‐losing nephropathy
Author(s) -
White Carrie R.,
Langston Cathy,
Hohenhaus Ann E.,
Lamb Kenneth,
Hackner Susan,
Fox Philip R.
Publication year - 2015
Publication title -
journal of veterinary emergency and critical care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.886
H-Index - 47
eISSN - 1476-4431
pISSN - 1479-3261
DOI - 10.1111/vec.12409
Subject(s) - medicine , hypoalbuminemia , proteinuria , thromboelastography , blood pressure , creatinine , antithrombin , hypoproteinemia , population , serum albumin , cardiology , gastroenterology , heparin , coagulation , environmental health , kidney
Objective To determine whether hypercoagulability in proteinuric dogs, defined by thromboelastography (TEG), is related to the degree of proteinuria, presence of systemic arterial hypertension, presence of hypoalbuminemia, or reduced antithrombin activity. Design Prospective study of client‐owned dogs. Data collected from each patient included signalment, body weight, urine protein‐to‐creatinine ratio (UPC), serum albumin concentration, TEG values, noninvasive arterial blood pressure, and AT activity. Hypercoagulability was diagnosed by TEG and odds ratios for other measurements were assessed by univariate logistic regression. Setting Urban referral center and teaching hospital. Animals Seventy‐six dogs with protein‐losing nephropathy (PLN) based on UPC, diagnosed between Oct 2009 and Oct 2012. Interventions None. Measurements and Main Results The prevalence of hypercoagulability was 89%. No statistically significant associations were detected between hypercoagulability and UPC, serum albumin, noninvasive blood pressure, or AT activity (all P > 0.05). The prevalence of thromboembolism was 6.6%. Conclusions Hypercoagulability was prevalent in dogs with PLN but could not be predicted based upon the presence or degree of proteinuria, systemic arterial hypertension, hypoalbuminemia, or low AT activity. The prevalance of thromboembolism was low in this population with PLN.