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Plasma lactate concentrations and comparison of two point‐of‐care lactate analyzers to a laboratory analyzer in a population of healthy cats
Author(s) -
Tynan Beth,
Kerl Marie E.,
Jackson Mary L.,
Mann F. A.
Publication year - 2015
Publication title -
journal of veterinary emergency and critical care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.886
H-Index - 47
eISSN - 1476-4431
pISSN - 1479-3261
DOI - 10.1111/vec.12321
Subject(s) - medicine , cats , phlebotomy , point of care , spectrum analyzer , limits of agreement , population , point of care testing , confidence interval , blood lactate , nuclear medicine , pathology , blood pressure , heart rate , electrical engineering , environmental health , engineering
Objective To establish a reference interval for plasma lactate in a population of healthy adult cats on a laboratory analyzer (Nova Biomedical Critical Care Xpress [CCX]) and 2 commercially available point‐of‐care (POC) analyzers (Abbott i‐STAT [i‐STAT] and Nova Biomedical Lactate Plus [LP]), and to compare the level of agreement of lactate measurement between the laboratory analyzer and POC analyzers. Design Prospective observational study. Setting University veterinary teaching hospital. Animals Forty‐seven healthy adult cats. Interventions Jugular phlebotomy. Measurements and Main Results In this population, plasma lactate reference interval was 0.67–5.44 mmol/L for the CCX, 0.65–5.16 mmol/L for the i‐STAT, and 0.68–4.39 mmol/L for the LP. Comparisons were made between lactate measurements on 2 point‐of‐care analyzers and the laboratory analyzer using the Bland–Altman method. For the comparison of CCX and i‐STAT, the bias was −0.10 mmol/L; for the CCX and LP, the bias was −0.24 mmol/L. Conclusions Measurements of plasma lactate in cats using the i‐STAT showed acceptable agreement with the CCX. The LP showed weaker agreement. However, both POC analyzers are suitable for measurement of lactate in cats, provided results from different POC analyzers are not directly compared. This study identified a larger reference interval for plasma lactate concentration in cats than what has been previously reported.