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Effects of intravenous administration of tranexamic acid on hematological, hemostatic, and thromboelastographic analytes in healthy adult dogs
Author(s) -
Kelmer Efrat,
Segev Gilad,
Papashvilli Victoria,
RahimiLevene Naomi,
Bruchim Yaron,
Aroch Itamar,
Klainbart Sigal
Publication year - 2015
Publication title -
journal of veterinary emergency and critical care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.886
H-Index - 47
eISSN - 1476-4431
pISSN - 1479-3261
DOI - 10.1111/vec.12319
Subject(s) - medicine , thromboelastography , partial thromboplastin time , anesthesia , bolus (digestion) , prothrombin time , tranexamic acid , vomiting , fibrinogen , hemostasis , antithrombin , gastroenterology , surgery , coagulation , heparin , blood loss
Objective To assess the effects of tranexamic acid (TA) on hematological, hemostatic, and thromboelastographic analytes in healthy adult dogs. Design Prospective study. Setting University teaching hospital. Animals Eleven healthy, staff‐owned, adult dogs. Measurements and Main Results Dogs were administered TA as an IV bolus, followed by a 3‐hour constant rate infusion (CRI). Complete blood count, prothrombin time, activated partial thromboplastin time, D‐dimer, antithrombin, fibrinogen, and thromboelastography (TEG) were measured prior to, and immediately after TA administration. Vomiting occurred transiently in the first 2 treated dogs, immediately after 20 and 15 mg/kg IV boluses, but not during the CRI. In all other dogs the TA IV bolus dose was reduced to 10 mg/kg, and administered slower, and vomiting did not occur. All measured hemostatic and hematological analytes remained within their reference intervals, however, following TA treatment, significant decreases were recorded in prothrombin time, TEG R and A30 values, Hct, and hemoglobin concentration, while the TEG LY30 significantly increased. Conclusions Administration of TA as a slow IV bolus at 10 mg/kg, followed by a 10 mg/kg/h CRI over 3 hours to healthy dogs is safe; however, its effect on TEG A30, A60, LY30, and LY60 values was inconsistent with its expected anti‐fibrinolytic properties.