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Evaluation of the i‐STAT portable point‐of‐care analyzer for determination of blood gases and acid–base status in newborn calves
Author(s) -
Bleul Ulrich,
Götz Eva
Publication year - 2014
Publication title -
journal of veterinary emergency and critical care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.886
H-Index - 47
eISSN - 1476-4431
pISSN - 1479-3261
DOI - 10.1111/vec.12228
Subject(s) - spectrum analyzer , medicine , venous blood , base excess , limiting , blood lactate , limits of agreement , anesthesia , nuclear medicine , blood pressure , computer science , telecommunications , mechanical engineering , heart rate , engineering
Objective To validate the i‐STAT, a portable hand‐held analyzer that allows point‐of‐care measurement of blood gases, acid–base, lactate, and other blood variables in food animal practice for analysis of blood samples of newborn calves. Design Prospective observational study. Setting University teaching hospital. Measurements and Main Results A total of 271 venous blood samples were analyzed for PvO 2 , PvCO 2 , pH, base excess (BE), HCO 3 , venous saturation of oxygen (SvO 2 ), and total carbon dioxide (TCO 2 ) using an i‐STAT and a Rapidlab 248 bench top analyzer that served as the reference method. l ‐lactate was measured using the i‐STAT as well as photometrically. Results from the i‐STAT and the reference methods were compared. The analytes BE, HCO 3 , and TCO 2 showed a constant systematic error across the entire range with 2.3, 1.9, and 2.0 mmol/L lower values, respectively, than the values measured by the reference method. Based on the combined inherent imprecision of the 2 analyzers and after correcting the influences of systematic errors, the PvO 2 , HCO 3 , and SvO 2 were within the acceptable limits in 76% to 91% of the cases. Ninety‐five percent of the measurements of PvCO 2 and BE were within acceptable limits. Conclusions The overall performance of the i‐STAT was good except for BE, HCO 3 , and TCO 2 , thus limiting its usefulness in clinical studies. However this hand‐held device allows rapid, reliable, and accurate point‐of‐care blood analyses and thus can be useful in bovine practice.