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Decreased postoperative C‐reactive protein production in dogs with pyometra through the use of low‐dose ketamine
Author(s) -
Liao PeiYu,
Chang ShiChieh,
Chen KuanSheng,
Wang HsienChi
Publication year - 2014
Publication title -
journal of veterinary emergency and critical care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.886
H-Index - 47
eISSN - 1476-4431
pISSN - 1479-3261
DOI - 10.1111/vec.12178
Subject(s) - pyometra , medicine , ketamine , perioperative , anesthesia , c reactive protein , surgery , inflammation , uterus
Objective To determine the effects of subanesthetic ketamine in dogs with pyometra on C‐reactive protein (CRP) concentrations following surgery. Design Prospective, nonconcealed, alternating allocation controlled trial. Setting Veterinary teaching hospital. Animals Sixteen dogs diagnosed with pyometra. Interventions The tentative diagnosis of canine pyometra was based on compatible history, physical examination findings, ultrasonographic findings, and hematological evaluation. Two different anesthesia and analgesic protocols with and without low‐dose ketamine were used during and following ovariohysterectomy in 16 female dogs ( n = 8 per group) that were diagnosed with naturally occurring pyometra. Dogs were sequentially allocated to treatment groups in an alternating fashion without concealment. Serum was collected before, 24, and 48 hours after surgery for CRP measurement. Measurements and main results Perioperative physical parameters in the 2 groups of dogs were similar. The serum concentrations of CRP in both groups were essentially the same before surgery, but significantly increased in the control group and decreased in ketamine group at 48 hours after surgery. Conclusions Low‐dose ketamine attenuated the postoperative concentration of serum CRP in dogs with pyometra compared with dogs that did not receive ketamine in the perioperative period. Further studies are warranted to determine the clinical implications of these findings.