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Status epilepticus attributed to inadvertent intrathecal injection of cefazolin during myelography
Author(s) -
Griffith Carrie A.,
Hoffmann Daniel E.
Publication year - 2013
Publication title -
journal of veterinary emergency and critical care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.886
H-Index - 47
eISSN - 1476-4431
pISSN - 1479-3261
DOI - 10.1111/vec.12117
Subject(s) - medicine , cefazolin , status epilepticus , anesthesia , intrathecal , myelography , subarachnoid space , lumbar puncture , lumbar , epilepsy , surgery , spinal cord , cerebrospinal fluid , antibiotics , psychiatry , microbiology and biotechnology , biology
Abstract Objective To describe a case of status epilepticus believed to be a consequence of inadvertent intrathecal administration of cefazolin in a dog undergoing a myelogram. Case Summary A 4‐year‐old, 6.5 kg, male neutered Dachshund was referred for evaluation of an acute onset hind limb paraparesis. While performing a lumbar myelogram, cefazolin was inadvertently injected into the ventral subarachnoid space. Subsequent refractory seizure activity was attributed to the epileptogenic effects of intrathecally administered cefazolin. Supportive therapy led to eventual complete recovery. New or Unique Information Provided Although epileptogenic effects of intrathecally administered cefazolin are well documented in the human and experimental animal model literature, to the authors’ knowledge this has not been characterized in the veterinary literature. This case highlights the need to be diligent and mindful when one administers medications, and describes the management of a dog adversely affected as a consequence of a medical error.