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Efficacy of olanexidine gluconate in canine superficial pyoderma: a randomised, single‐blinded controlled trial
Author(s) -
Hsiao YunHsia,
Imanishi Ichiro,
Iyori Keita
Publication year - 2021
Publication title -
veterinary dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.744
H-Index - 60
eISSN - 1365-3164
pISSN - 0959-4493
DOI - 10.1111/vde.13038
Subject(s) - staphylococcus pseudintermedius , pyoderma , medicine , antiseptic , broth microdilution , minimum inhibitory concentration , shampoo , chlorhexidine , randomized controlled trial , antimicrobial , dermatology , surgery , staphylococcus aureus , staphylococcus , dentistry , microbiology and biotechnology , pathology , biology , bacteria , genetics
Background Topical treatments can be beneficial for managing canine superficial pyoderma. A novel antiseptic agent, olanexidine gluconate, has become available recently for use in humans, and its efficacy for canine pyoderma as topical therapy is unknown. Objective The antimicrobial effect of olanexidine was evaluated using minimal inhibitory concentration (MIC) towards Staphylococcus pseudintermedius . Furthermore, its clinical efficacy in canine superficial pyoderma was assessed in a randomized, single‐blinded study. Animals Twenty‐eight client‐owned dogs with atopic dermatitis and superficial pyoderma. Methods and materials The MIC of olanexidine was determined for S. pseudintermedius isolates (n=73) by serial dilution of 96‐well broth microdilution method. Regarding the clinical trial, all recruited dogs were randomized into two groups; one treated with 1.5% olanexidine spray once daily and the other with a 3% chlorhexidine shampoo once a week for 2 times, respectively. Clinical assessment was performed at days 0 and 14 according to the guidelines of the Japanese Society of Antimicrobials for Animals. Results The MIC values for methicillin‐resistant S. pseudintermedius (MRSP) and methicillin‐sensitive S. pseudintermedius (MSSP) were 0.23 μg/ml and 0.24 μg/ml (P =0.9), respectively. In clinical trial, olanexidine and chlorhexidine showed substantial improvement in clinical presentation compared to the baseline. Conclusions and clinical importance Olanexidine showed comparable efficacy to chlorhexidine (P=0.73). Moreover, the MIC against S. pseudintermedius indicated high bactericidal activity, which was supported by the topical effectiveness of olanexidine.