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Long‐term successful treatment of a donkey with cutaneous lupus erythematous with methotrexate
Author(s) -
Mosca Marion,
RandleffRasmussen Pia,
Milhau Nadège,
Panzuti Pauline,
Meylan Myriam,
Desjardin Isabelle,
Pin Didier
Publication year - 2020
Publication title -
veterinary dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.744
H-Index - 60
eISSN - 1365-3164
pISSN - 0959-4493
DOI - 10.1111/vde.12847
Subject(s) - methotrexate , medicine , donkey , dermatology , erythema , skin biopsy , cutaneous lupus erythematosus , biopsy , incisional biopsy , histopathological examination , lupus erythematosus , systemic lupus erythematosus , pathology , surgery , immunology , antibody , disease , ecology , biology
Cutaneous lupus erythematosus (CLE) is a rare immune‐mediated dermatitis. To the best of the authors’ knowledge it has not been described in donkeys. A 5‐year‐old male neutered donkey, living in south‐east France, was diagnosed with CLE. Clinical signs included generalized symmetrical areas of alopecia, erythema, crusting and scales. Diagnostic tests included examination of skin biopsy samples by histopathological and immunohistochemical analysis which demonstrated an interface dermatitis with CD8+ T cells. The skin condition was successfully treated initially with glucocorticoids and methotrexate; successful long‐term maintenance was associated with administration of methotrexate.