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Chronic progressive lymphoedema in Friesian horses: suggestive phenotype of affected horses and genome‐wide association study
Author(s) -
Affolter Verena K.,
Dalley Brittany,
Kass Philip H.,
Brown Emily A.,
Sonder Claudia,
Bannasch Dannika L.
Publication year - 2020
Publication title -
veterinary dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.744
H-Index - 60
eISSN - 1365-3164
pISSN - 0959-4493
DOI - 10.1111/vde.12831
Subject(s) - genome wide association study , single nucleotide polymorphism , genotyping , snp , genetic association , biology , medicine , equidae , snp genotyping , veterinary medicine , genetics , genotype , gene , paleontology
Background Chronic progressive lymphoedema (CPL) is a disabling condition affecting various draft horse breeds, including Friesian horses. Hypothesis The high incidence of CPL in Friesian horses suggests a genetic component and a predisposing phenotype. Animals For the genomic study, 26 affected and 19 control horses were evaluated. Body measurements were taken from 28 affected and nine control Friesian horses. Methods and materials Axiom® Equine Genotyping Array with a total of 307,474 single nucleotide polymorphism (SNPs) was used for the case/control genome‐wide association study (GWAS). Height, weight and leg measurements (seven different body measurements) were obtained and compared between groups. Results No significant associations were identified with the GWAS. There were significant differences ( P < 0.05) in gaskin length measurements between CPL‐affected horses and controls. Conclusion The current study suggests that the potential genetic contribution to CPL in Friesian horses is complex and may include other SNP‐associated factors. Significantly increased gaskin length of affected horses suggests a phenotype prone to developing CPL.