Premium
Serum IgE against cross‐reactive carbohydrate determinants ( CCD ) in healthy and atopic dogs
Author(s) -
Piccione Michelle L.,
DeBoer Douglas J.
Publication year - 2019
Publication title -
veterinary dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.744
H-Index - 60
eISSN - 1365-3164
pISSN - 0959-4493
DOI - 10.1111/vde.12799
Subject(s) - immunoglobulin e , atopic dermatitis , immunology , medicine , serology , clinical significance , antibody , multiplex , atopy , allergen , allergy , pathology , biology , bioinformatics
Background Cross‐reactive carbohydrate determinants (CCD) are Immunoglobulin E (IgE)‐binding carbohydrate structures common to plant and insect species. In people, anti‐ CCD IgE is thought to be clinically irrelevant, but to have the potential to confound serological IgE test interpretations. Previous studies reported the detection of anti‐ CCD IgE in 24–73% of atopic dog sera; prevalence in healthy dogs has not been reported. Objective To compare the prevalence of anti‐ CCD IgE in a group of healthy and atopic dogs. Animals Sera from 61 healthy dogs and 101 dogs with a clinical diagnosis of atopic dermatitis were analyzed for IgE against CCD . Methods and materials Sera were analyzed for the presence of anti‐ CCD IgE and IgE against environmental allergens using a commercial multiplex allergen‐specific IgE assay. Results Anti‐ CCD IgE was detected in 17 of 101 (16.8%) atopic dog sera and eight of 61 (13.1%) healthy dog sera ( P = 0.65, Fisher's exact test). All healthy and atopic dogs with anti‐ CCD IgE had strong reactivity to grass pollens. Conclusions and clinical importance A similar prevalence of anti‐ CCD IgE was found in healthy and atopic dogs. Further investigation is warranted to determine the clinical significance of anti‐ CCD IgE antibodies in dogs, how they are best detected and if blocking these antibodies during diagnostic testing has clinical value.