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Phenotypic analysis of mice xenografted with canine epitheliotropic cutaneous T‐cell lymphoma cells
Author(s) -
Ikeuchi Miho,
Asahina Ryota,
Nishida Hidetaka,
Kamishina Hiroaki,
Kitoh Katsuya,
Sakai Hiroki,
Maeda Sadatoshi
Publication year - 2018
Publication title -
veterinary dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.744
H-Index - 60
eISSN - 1365-3164
pISSN - 0959-4493
DOI - 10.1111/vde.12650
Subject(s) - nod , lymph , spleen , pathology , lymphoma , cutaneous t cell lymphoma , phenotype , pathogenesis , metastasis , biology , medicine , cancer research , immunology , cancer , mycosis fungoides , gene , biochemistry , genetics
Background In canine epitheliotropic cutaneous T‐cell lymphoma ( ECTCL ), neoplastic cells cause skin lesions and potentially metastasize to lymph nodes, blood and other organs. Murine models are potentially valuable for elucidating the molecular mechanisms responsible for regulation of ECTCL cell migration. Hypothesis/Objectives To describe a phenotype of mice xenografted with canine ECTCL cells ( EO ‐1 cells). Animals Four NOD . CB 17‐ Prkdc scid /J ( NOD SCID ) mice were used. Methods and materials EO ‐1 cells were subcutaneously xenografted into NOD SCID mice. After four weeks, the development of tumour lesions in skin and other organs was investigated .Results Mice developed skin lesions with metastasis to the lymph nodes, spleen, lung, blood and liver. Conclusions and clinical importance Mice xenografted with EO ‐1 cells may be useful for studying the pathogenesis of canine ECTCL .