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Selected serum oxidative stress biomarkers in dogs with non‐food‐induced and food‐induced atopic dermatitis
Author(s) -
Almela Ramón M.,
Rubio Camila P.,
Cerón José J.,
Ansón Agustina,
Tichy Alexander,
Mayer Ursula
Publication year - 2018
Publication title -
veterinary dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.744
H-Index - 60
eISSN - 1365-3164
pISSN - 0959-4493
DOI - 10.1111/vde.12525
Subject(s) - atopic dermatitis , trolox equivalent antioxidant capacity , oxidative stress , medicine , pathogenesis , antioxidant capacity , antioxidant , gastroenterology , immunology , biochemistry , chemistry
Background Oxidative stress ( OS ) has been shown to be involved in the pathogenesis of human and canine atopic dermatitis ( AD ) through several distinct mechanisms. Selected serum biomarkers of OS (sb OS ) have been validated in normal dogs and studied in several canine diseases. To the best of the authors’ knowledge, the sb OS evaluated in this study have not previously been described in canine AD . Hypothesis/Objectives The aims of the study were to evaluate a panel of sb OS in dogs with food‐induced ( FIAD ) and non‐food‐induced ( NFIAD ) AD : cupric reducing antioxidant capacity ( CUPRAC ), ferrous oxidation‐xylenol orange ( FOX ), ferric reducing ability of the plasma ( FRAP ), paraoxonase‐1 ( PON 1), trolox equivalent antioxidant capacity ( TEAC ) and serum total thiol ( THIOL ). The aim was to compare these metabolites with those in healthy control dogs, and to correlate sb OS with validated pruritus and CADESI ‐04 severity scales in dogs with AD . Animals Forty six healthy, nine NFIAD and three FIAD client‐owned dogs were included. Methods The study was designed as a cohort study. Results There were significant differences in atopic dogs when compared to healthy dogs for all of the sb OS analysed. Conclusions and clinical relevance These findings suggest that OS could play a role in the pathogenesis of canine NFIAD and FIAD . In addition, the evaluation of sb OS could be useful for precision medicine to help to detect atopic dogs that might benefit from antioxidant‐targeted therapies.