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Pilot evaluation of the antipruritic efficacy of a topical transient receptor potential melastatin subfamily 8 ( TRPM 8) agonist in dogs with atopic dermatitis and pedal pruritus
Author(s) -
TamamotoMochizuki Chie,
Murphy K. Marcia,
Olivry Thierry
Publication year - 2018
Publication title -
veterinary dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.744
H-Index - 60
eISSN - 1365-3164
pISSN - 0959-4493
DOI - 10.1111/vde.12486
Subject(s) - medicine , atopic dermatitis , placebo , antipruritic , agonist , visual analogue scale , anesthesia , dermatology , receptor , alternative medicine , pathology
Background Atopic dermatitis ( AD ) requires a multimodal therapy and there is a need for effective adjunctive interventions. TRPM8 agonists are known to alleviate pruritus by inducing cooling. Objectives To evaluate the efficacy of a novel TRPM 8 agonist, 1‐diisopropylphosphorylheptane (Cryosim‐1), in atopic dogs. Animals Nine client owned dogs with moderate to severe pedal pruritus associated with nonseasonal AD . Methods This was a prospective, randomized, double‐blinded, intraindividual, placebo‐controlled study. A 2% Cryosim‐1 or placebo‐vehicle cream was applied to each forepaw twice daily for seven days. The owner rated the pruritus manifestations once daily using a pedal Pruritus Visual Analog Scale ( PVAS ) and provided a Owner's Global Assessment of Treatment Efficacy ( OGATE ) at study end. Results After seven days, the numbers of dogs with a pedal PVAS <2.0 for Cryosim‐1 and placebo were three and five of nine, respectively; likewise, OGATE scores of good‐to‐excellent were two and five of eight, respectively – these proportions were not significant between treatment groups ( P = 0.32 and 0.16, respectively). Furthermore, there was no significant difference between Cryosim‐1 and placebo in the median percentage change from baseline PVAS (47% versus 75%; P = 0.15) and in the number of dogs with a ≥50% or a ≥90% reduction from baseline pedal PVAS (four of nine versus five of nine, P = 0.50; two of nine versus two of nine, P = 0.72). Conclusions In this pilot trial with a TRPM 8 agonist in atopic dogs with pedal pruritus, the twice daily application of a 2% Cryosim‐1 cream did not have an antipruritic effect superior to that of its vehicle.