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Reversible and cachexia‐associated feline skin fragility syndrome in three cats
Author(s) -
Furiani Nicla,
Porcellato Ilaria,
Brachelente Chiara
Publication year - 2017
Publication title -
veterinary dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.744
H-Index - 60
eISSN - 1365-3164
pISSN - 0959-4493
DOI - 10.1111/vde.12457
Subject(s) - medicine , cats , cachexia , pathology , connective tissue , pathogenesis , dermis , eosinophilic , feline infectious peritonitis , dermatology , covid-19 , cancer , disease , infectious disease (medical specialty)
Background Feline skin fragility syndrome ( FSFS ) is an acquired disorder characterized by altered collagen production resulting in an extremely thin and fragile skin. FSFS is associated with diseases characterized by excessive steroidal hormones that can inhibit collagen synthesis. It is also described concomitantly with severe inflammatory, infectious or neoplastic conditions where the pathogenesis remains largely unknown. Objectives To describe three cases of FSFS in cats that become cachectic secondary to different causes without glucocorticoid involvement. To describe the histopathological features of connective tissue for both fragile skin and the skin after healing. Results All cats developed cachexia in less than two months (body condition score ranging from 1–1.5). Concomitant diseases were diagnosed in Case 1 (aspiration pneumonia due to mega‐oesophagus) and Case 2 (feline immunodeficiency virus ( FIV )). In Case 3, malnutrition was suspected as a primary cause. The main histological feature of fragile skin was an atrophic dermis with pale eosinophilic, thin and irregular collagen fibres with numerous red cores observed with Masson's stain. Elastic fibres were normal. Postrecovery histopathological findings at 11 (Case 1) and six months (Case 3) after diagnosis, indicated normalization of the collagen and of the whole skin as compared with controls. Conclusions and clinical importance To the best of the authors’ knowledge, this is the first report describing a reversible, nonsteroid‐induced FSFS , associated with rapidly developing cachexia in cats.