Premium
Detection of DNA sequences from a novel papillomavirus in a feline basal cell carcinoma
Author(s) -
Munday John S.,
French Adrienne,
Thomson Neroli
Publication year - 2017
Publication title -
veterinary dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.744
H-Index - 60
eISSN - 1365-3164
pISSN - 0959-4493
DOI - 10.1111/vde.12402
Subject(s) - basal cell carcinoma , human papillomavirus , dna , bovine papillomavirus , basal (medicine) , biology , virology , microbiology and biotechnology , basal cell , medicine , genetics , gene , genome , insulin
Background Basal cell carcinomas ( BCC s) are uncommon feline skin neoplasms of uncertain cause. Case A 14‐year‐old Abyssinian cat developed a soft dermal nodule on the dorsal thorax. This mass grew slowly over a six month period before being surgically excised. Methods and results Histology revealed a BCC . Additionally, changes suggestive of an early Bowenoid in situ carcinoma ( BISC ) were present in the overlying epidermis. Both the BCC and the BISC contained papillomavirus‐induced cell changes and prominent basophilic intracytoplasmic bodies. PCR using consensus primers and primers specific for Felis catus papillomavirus types 2 and 3 (Fca PV ‐2 and ‐3) was used to amplify papillomaviral DNA . The same papillomaviral DNA sequence was present in the BCC and the BISC . This sequence was most similar to Fca PV ‐3, but with just 70.5% similarity, was from a novel papillomavirus type. No recurrence or further masses developed. Conclusions This case is unusual due to the presence of a large dermal BCC associated with minimal BISC changes in the overlying epidermis. Additionally, papillomavirus‐induced cell changes have not been described previously in a BCC . Furthermore, both the BCC and the BISC contained sequences from a novel papillomavirus type. These observations suggest that the development of some BCC s could be influenced by papillomavirus infection. The novel papillomavirus type detected is the third papillomavirus type to be associated with skin cancer in cats.