Premium
Cutaneous form of maculopapular mastocytosis in a foal
Author(s) -
Junginger Johannes,
Geburek Florian,
Khan Muhammad Akram,
Müller Gundi,
Gruber Achim D.,
HewickerTrautwein Marion
Publication year - 2016
Publication title -
veterinary dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.744
H-Index - 60
eISSN - 1365-3164
pISSN - 0959-4493
DOI - 10.1111/vde.12308
Subject(s) - cutaneous mastocytosis , medicine , pathology , foal , systemic mastocytosis , urticaria pigmentosa , mastocytoma , histopathology , mast cell , skin biopsy , biopsy , dermatology , bone marrow , immunology , biology , cancer research , tumor cells , genetics
Background Cutaneous mastocytosis is a rare benign disease occurring in domestic animals and humans. In previous reports, dermal findings in foals were accompanied by systemic mast cell infiltrations, whereas lesions in human cutaneous mastocytosis, including urticaria pigmentosa and solitary mastocytoma, are usually restricted to the skin. Objectives To describe a new variant of equine cutaneous maculopapular mastocytosis lacking systemic involvement. Animals A 2.5‐month‐old warmblood foal with multiple skin nodules since birth. Methods Clinical examination (including haematology, fine needle biopsy and thoracic radiographs), postmortem examination, histopathology and immunohistochemistry. Results Clinical examination showed 41 skin nodules that contained numerous mast cells as detected by cytology. Macroscopic examination at postmortem examination revealed intradermal circumscribed lesions ranging from 2 to 5 cm in diameter. Histologically, they were composed of well differentiated mast cells with metachromatic granules stained with toluidine blue accompanied by many eosinophils. Immunohistochemically, mast cells had mast cell growth factor receptor c‐ KIT predominating at the cell surface and intracytoplasmic expression of tryptase. In other organs similar mast cell infiltrations were not detected. Conclusions and clinical importance The case presented here fulfils the criteria of equine cutaneous maculopapular mastocytosis ( ECMM ), representing a rare entity in foals that is reported to be associated with spontaneous regression, although the long‐term prognosis is not known. Unlike in previous reports, lesions described here were restricted to the skin. This may imply that ECMM is primarily a dermal disease sharing similarities with urticaria pigmentosa in young children.