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Canine epidermolysis bullosa acquisita: a retrospective study of 20 cases
Author(s) -
Bizikova Petra,
Linder Keith E.,
Wofford Jessica A.,
Mamo Lisa B.,
Dunston Stanley M.,
Olivry Thierry
Publication year - 2015
Publication title -
veterinary dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.744
H-Index - 60
eISSN - 1365-3164
pISSN - 0959-4493
DOI - 10.1111/vde.12255
Subject(s) - epidermolysis bullosa acquisita , medicine , histopathology , prednisone , dermatology , epidermolysis bullosa , pathology , gastroenterology , bullous pemphigoid , immunology , antibody
Background Epidermolysis bullosa acquisita ( EBA ) is a rare autoimmune subepidermal blistering disease of dogs and humans. Objectives Our objectives were to describe clinical phenotypes, histopathology and treatment outcomes of canine EBA . Animals Twenty dogs diagnosed with EBA based on a subepidermal blister formation and collagen VII autoreactivity. Results Most dogs were young (median: 1.2‐year‐old) with a male‐to‐female ratio of 2.3:1. Nine of 20 dogs (45%) developed lesions before one year of age and 11 of 20 dogs (55%) were great danes. Tense vesicles and bullae (18 of 20; 90%) and deep erosions and ulcers (20 of 20; 100%) were the most common lesions and these affected predominantly the oral cavity (19 of 20; 95%), pinnae (16 of 20; 80%), axillae (15 of 20; 75%) and footpads (14 of 20; 70%). Histopathology identified neutrophilic perivascular dermatitis (17 of 17; 100%) without or with (12 of 17; 71%) eosinophils, which occasionally equalled (four cases) or outnumbered neutrophils (two cases). Subepidermal vesicles were either devoid of inflammation or contained neutrophils with or without eosinophils, fibrin and/or haemorrhage. A complete remission of skin lesions was obtained in 14 dogs with a median time of 58 days. Glucocorticoids were used in these dogs either as a monotherapy (3 of 14; 21%) or in combination with other immunomodulating drugs (11 of 14; 79%). The median dose of prednisone was 3 mg/kg/day. The remaining six dogs were euthanized. Conclusions and clinical importance Canine EBA is a rare subepidermal blistering disease with an inflammatory phenotype and a predilection for young great danes and male dogs. The outcome of treatment appears more favourable than assumed previously.