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Background  Wipes containing chlorhexidine and azole derivates have been recommended for veterinary use. No study has been published about their activity against  Malassezia pachydermatis .    Hypothesis/Objectives  To evaluate the  in vivo  and  in vitro  activity of wipes soaked in a chlorhexidine, climbazole and Tris‐ EDTA  solution against  Malassezia pachydermatis .    Animals  Five research colony shar‐pei dogs.    Methods  Wipes were applied once daily onto the left axilla, left groin and perianal area (protocol A), and twice daily on the right axilla, right groin and umbilical region (protocol B) for 3 days.  In vivo  activity was evaluated by quantifying  Malassezia  colonies through contact plates on the selected body areas before and after wipe application. The activity of the solution in which the wipes were soaked was assessed  in vitro  by contact tests following the European Standard  UNI EN  1275 guidelines.    Results  Samples collected after wipe application showed a significant and rapid reduction of  Malassezia  yeast  CFU . No significant difference in the  Malassezia  reduction was found between protocols A and B.  In vitro  assay showed 100% activity against  Malassezia  yeasts after a 15 min contact time with the wipe solution.    Conclusions and clinical importance  Wipes containing chlorhexidine, climbazole and Tris‐ EDTA  substantially reduced the  M. pachydermatis  population on the skin of dogs. The results, although this was an uncontrolled study performed on a small number of dogs, suggest that these wipes may be useful for topical therapy of  Malassezia  dermatitis involving the lips, paws, perianal area and skin folds.

veterinary dermatology

A pilot study of the efficacy of wipes containing chlorhexidine 0.3%, climbazole 0.5% and Tris‐ EDTA  to reduce  Malassezia pachydermatis  populations on canine skin